Thursday, November 15, 2012
The changing nature of truth, and warfarin for afib
I am presently really excited about learning all over again what I thought I knew when I finished my medical education about 25 years ago. Since that time I have become wiser, learning how to do things and what works for patients by practicing medicine and reading literature. I also retain a body of knowledge that I absorbed from my grand old doctor professors at Johns Hopkins which is sacred and dear and not necessarily true.
Just recently in my e-mail I got an invitation from the makers of the MKSAP (the Medical Knowledge Self-Assessment Program which I used in studying for my internal medicine boards) to answer a set of not-ready-for-primetime questions in the various subspecialties, for which I will be rewarded with a chance to get the next MKSAP materials for free. I must answer these questions without using outside materials and the answers from all of the folks who do this will be used to standardize the test.
I took the endocrinology section first and had an answer for each of the questions, based on what has been true over the last two decades. I then looked on UpToDate, the online resource that is updated constantly by recognized experts in every field, to find whether I had been right, and yes, sometimes I was right. But the answers I found didn't necessarily even correlate with the multiple choice answers, obviously also written by worlds' experts. So on subjects about which it is critical to do the right thing, it is really not clear what that is.
When I graduated from medical school I knew the right answer to questions that were of the ilk where there might be a right answer. Like "Is chemotherapy helpful for pancreatic cancer?" or "What are the most effective antibiotics for a simple urinary tract infection?" At some unclear moment in time, those and many other answers that I knew were no longer correct.
While cruising UpToDate I chanced upon a page called "Practice Changing UpDates" in which I found that a whole bunch of things that we do are wrong. I always feel warm inside when I find out that something that had seemed unnecessarily painful or expensive or complex is of no value. I wonder, though, how soon these new recommendations will also be wrong and when, perhaps, the previous ones will be right again, or whether the whole thing is a huge oversimplification and everything we've ever done was perhaps right, given the appropriate circumstances.
But a larger issue, for me, is the fact that it is now completely impractical to be an expert in the field of medicine, unless perhaps the field of knowledge to which on aspires to have wisdom is itty bitty. Research is just happening so very fast, communication is nearly instantaneous and discussion amongst the many diverse practitioners who very much have a right to their own educated and experienced opinion is limited.
For instance, last night I heard another physician tell a patient that he shouldn't drink so much coffee because he was having heart arrhythmias and the coffee would make it worse. He had heard a cardiologist say this and berate another physician for allowing a patient with a heart attack to have a cup of coffee. Studies show that coffee doesn't cause heart arrhythmias and that it is in general good for people is large quantities, reducing risk of liver disease, diabetes and all sorts of realms of misery. But certainly the studies that purport to show that coffee is of no harm and nearly infinite help are not designed to look at this particular individual's risk from caffeine, which definitely can cause an increase in heart rate (check your own pulse after a strong cup if you are not a habitual drinker.) What is true, then, about coffee, or anything else for that matter?
But all that said, I do think the news from UpToDate as of September 20, 2012 is pretty interesting, if not necessarily true.
Of the clinical pearls in the article, three stand out as particularly relevant to my practice. First, people with allergy to eggs CAN get a flu shot, even though it is made with eggs, because there is hardly ever any problem. They should be observed for 30 minutes where there are personnel capable of handling an allergy issue after vaccination, but they can go ahead and be vaccinated. The question of how important vaccination is for healthy adults and children is, of course, not addressed, and is still very controversial.
The second is that UpToDate recommends use of Pradaxa (dabigatran), Xarelto (rivaroxaban) or apixaban for prevention of strokes in patients with atrial fibrillation rather than Coumadin (warfarin.) I have written several articles about these new drugs which reduce the ability of the blood to clot and do not require monthly blood test monitoring. They are not easily reversible should abnormal bleeding occur, but honestly neither is warfarin, and the risk of bleeding is so much higher with it because of all of its drug and food interactions and its tendency to be taken wrong. The new drugs are more expensive, but with the expense of monitoring and paying for the morbidity from bleeding or clotting when using warfarin, the costs will end up being similar, and much less once there are generic options. There have been studies looking at various possible risks of the new drugs, including more heart attacks with the use of Pradaxa (dabigatran) but the vast magnitude of error related illness with warfarin dwarfs these risks.
And still. After all of my ranting, I am absolutely positive that many patients will still find that warfarin is the best drug for preventing clotting. There are many people whose doses are always perfect and have absolutely no problems, monitor their own blood tests at home without difficulty and the drug is, in fact, cheap. I could go on with pros and cons for a very long time, but I won't.
I would really like to see these new anticoagulants replace most of the injectable anticoagulants such as enoxaparin and dalteparin since this will profoundly change the way we treat patients with artificial heart valves and blood clotting disorders such as pulmonary embolism.
Last on the "Oh, cool. Finally." list is that it is unnecessary to follow liver function tests for people taking statin drugs such as Lipitor (atorvastatin), Crestor (rosuvastatin) and simvastatin. They are not liver toxic. We thought they were and they aren't. Again, like with the flu shot, the question of whether so many people should be taking these drugs is begged, but at least they don't need to get blood tests all the time. They also don't need to get their cholesterol levels checked all the time if they are on a dose that is stable and works, but that isn't part of the article, just information from long ago that still hasn't made its way into standard medical practice.
Janice Boughton, MD, ACP Member, practiced in the Seattle area for four years and in rural Idaho for 17 years before deciding to take a few years off to see more places, learn more about medicine and increase her knowledge base and perspective by practicing hospital and primary care medicine as a locum tenens physician. She lives in Idaho when not traveling. Disturbed by various aspects of the practice of medicine that make no sense and concerned about the cost of providing health care to every American, she blogs at Why is American Health care so expensive?, where this post originally appeared.
Contact ACP Internist
Send comments to ACP Internist staff at firstname.lastname@example.org.
- QD: News Every Day--Exercise may reduce biomarkers...
- A skeptical look at weight loss, exercise and prev...
- Knee replacements on the rise
- QD: News Every Day--End-of-life planning reduces a...
- Beating the importance of bike helmets into everyo...
- QD: News Every Day--Hospital cites regimen to figh...
- Can infographics make reading journals easier?
- Why I can't quite be okay with 'Okay at Any Size'
- QD: News Every Day--Plan for patient preferences
- A new medication that is sure to succeed
Members of the American College of Physicians contribute posts from their own sites to ACP Internistand ACP Hospitalist. Contributors include:
Albert Fuchs, MD, FACP, graduated from the University of California, Los Angeles School of Medicine, where he also did his internal medicine training. Certified by the American Board of Internal Medicine, Dr. Fuchs spent three years as a full-time faculty member at UCLA School of Medicine before opening his private practice in Beverly Hills in 2000.
And Thus, It Begins
Amanda Xi, ACP Medical Student Member, is a first-year medical student at the OUWB School of Medicine, charter class of 2015, in Rochester, Mich., from which she which chronicles her journey through medical training from day 1 of medical school.
Ira S. Nash, MD, FACP, is the senior vice president and executive director of the North Shore-LIJ Medical Group, and a professor of Cardiology and Population Health at Hofstra North Shore-LIJ School of Medicine. He is Board Certified in Internal Medicine and Cardiovascular Diseases and was in the private practice of cardiology before joining the full-time faculty of Massachusetts General Hospital.
Zackary Berger, MD, ACP Member, is a primary care doctor and general internist in the Division of General Internal Medicine at Johns Hopkins. His research interests include doctor-patient communication, bioethics, and systematic reviews.
Controversies in Hospital
Run by three ACP Fellows, this blog ponders vexing issues in infection prevention and control, inside and outside the hospital. Daniel J Diekema, MD, FACP, practices infectious diseases, clinical microbiology, and hospital epidemiology in Iowa City, Iowa, splitting time between seeing patients with infectious diseases, diagnosing infections in the microbiology laboratory, and trying to prevent infections in the hospital. Michael B. Edmond, MD, FACP, is a hospital epidemiologist in Iowa City, IA, with a focus on understanding why infections occur in the hospital and ways to prevent these infections, and sees patients in the inpatient and outpatient settings. Eli N. Perencevich, MD, ACP Member, is an infectious disease physician and epidemiologist in Iowa City, Iowa, who studies methods to halt the spread of resistant bacteria in our hospitals (including novel ways to get everyone to wash their hands).
db's Medical Rants
Robert M. Centor, MD, FACP, contributes short essays contemplating medicine and the health care system.
Suneel Dhand, MD, ACP Member
Suneel Dhand, MD, ACP Member, is a practicing physician in Massachusetts. He has published numerous articles in clinical medicine, covering a wide range of specialty areas including; pulmonology, cardiology, endocrinology, hematology, and infectious disease. He has also authored chapters in the prestigious "5-Minute Clinical Consult" medical textbook. His other clinical interests include quality improvement, hospital safety, hospital utilization, and the use of technology in health care.
Juliet K. Mavromatis, MD, FACP, provides a conversation about health topics for patients and health professionals.
Dr. Mintz' Blog
Matthew Mintz, MD, FACP, has practiced internal medicine for more than a decade and is an Associate Professor of Medicine at an academic medical center on the East Coast. His time is split between teaching medical students and residents, and caring for patients.
Toni Brayer, MD, FACP, blogs about the rapid changes in science, medicine, health and healing in the 21st century.
Vineet Arora, MD, FACP, is Associate Program Director for the Internal Medicine Residency and Assistant Dean of Scholarship & Discovery at the Pritzker School of Medicine for the University of Chicago. Her education and research focus is on resident duty hours, patient handoffs, medical professionalism, and quality of hospital care. She is also an academic hospitalist.
John H. Schumann, MD, FACP, provides transparency on the workings of medical practice and the complexities of hospital care, illuminates the emotional and cognitive aspects of caregiving and decision-making from the perspective of an active primary care physician, and offers behind-the-scenes portraits of hospital sanctums and the people who inhabit them.
Ryan Madanick, MD, ACP Member, is a gastroenterologist at the University of North Carolina School of Medicine, and the Program Director for the GI & Hepatology Fellowship Program. He specializes in diseases of the esophagus, with a strong interest in the diagnosis and treatment of patients who have difficult-to-manage esophageal problems such as refractory GERD, heartburn, and chest pain.
Mike Aref, MD, PhD, FACP, is an academic hospitalist with an interest in basic and clinical science and education, with interests in noninvasive monitoring and diagnostic testing using novel bedside imaging modalities, diagnostic reasoning, medical informatics, new medical education modalities, pre-code/code management, palliative care, patient-physician communication, quality improvement, and quantitative biomedical imaging.
William Hersh, MD, FACP, Professor and Chair, Department of Medical Informatics & Clinical Epidemiology, Oregon Health & Science University, posts his thoughts on various topics related to biomedical and health informatics.
David Katz, MD
David L. Katz, MD, MPH, FACP, is an internationally renowned authority on nutrition, weight management, and the prevention of chronic disease, and an internationally recognized leader in integrative medicine and patient-centered care.
Richard Just, MD, ACP Member, has 36 years in clinical practice of hematology and medical oncology. His blog is a joint publication with Gregg Masters, MPH.
Kevin Pho, MD, ACP Member, offers one of the Web's definitive sites for influential health commentary.
Michael Kirsch, MD, FACP, addresses the joys and challenges of medical practice, including controversies in the doctor-patient relationship, medical ethics and measuring medical quality. When he's not writing, he's performing colonoscopies.
Elaine Schattner, MD, FACP, shares her ideas on education, ethics in medicine, health care news and culture. Her views on medicine are informed by her past experiences in caring for patients, as a researcher in cancer immunology, and as a patient who's had breast cancer.
Mired in MedEd
Alexander M. Djuricich, MD, FACP, is the Associate Dean for Continuing Medical Education (CME), and a Program Director in Medicine-Pediatrics at the Indiana University School of Medicine in Indianapolis, where he blogs about medical education.
Rob Lamberts, MD, ACP Member, a med-peds and general practice internist, returns with "volume 2" of his personal musings about medicine, life, armadillos and Sasquatch at More Musings (of a Distractible Kind).
David M. Sack, MD, FACP, practices general gastroenterology at a small community hospital in Connecticut. His blog is a series of musings on medicine, medical care, the health care system and medical ethics, in no particular order.
Reflections of a Grady
Kimberly Manning, MD, FACP, reflects on the personal side of being a doctor in a community hospital in Atlanta.
The Blog of Paul Sufka
Paul Sufka, MD, ACP Member, is a board certified rheumatologist in St. Paul, Minn. He was a chief resident in internal medicine with the University of Minnesota and then completed his fellowship training in rheumatology in June 2011 at the University of Minnesota Department of Rheumatology. His interests include the use of technology in medicine.
Technology in (Medical)
Neil Mehta, MBBS, MS, FACP, is interested in use of technology in education, social media and networking, practice management and evidence-based medicine tools, personal information and knowledge management.
Peter A. Lipson,
Peter A. Lipson, MD, ACP Member, is a practicing internist and teaching physician in Southeast Michigan. The blog, which has been around in various forms since 2007, offers musings on the intersection of science, medicine, and culture.
Why is American Health Care So Expensive?
Janice Boughton, MD, FACP, practiced internal medicine for 20 years before adopting a career in hospital and primary care medicine as a locum tenens physician. She lives in Idaho when not traveling.
World's Best Site
Daniel Ginsberg, MD, FACP, is an internal medicine physician who has avidly applied computers to medicine since 1986, when he first wrote medically oriented computer programs. He is in practice in Tacoma, Washington.
Other blogs of note:
American Journal of
Also known as the Green Journal, the American Journal of Medicine publishes original clinical articles of interest to physicians in internal medicine and its subspecialities, both in academia and community-based practice.
A collaborative medical blog started by Neil Shapiro, MD, ACP Member, associate program director at New York University Medical Center's internal medicine residency program. Faculty, residents and students contribute case studies, mystery quizzes, news, commentary and more.
Michael Benjamin, MD, ACP member, doesn't accept industry money so he can create an independent, clinician-reviewed space on the Internet for physicians to report and comment on the medical news of the day.
The Public Library of Science's open access materials include a blog.
One of the most popular anonymous blogs written by an emergency room physician.