Primary care physicians can assure women that the possibility of a hysterectomy doesn't necessarily lead to a higher risk of heart disease. It's one less thing to worry about for a procedure that's could frighten any woman.
Contrary to previous retrospective studies, this prospective analysis showed that hysterectomy with or without ovarian conservation was not a key determinant of cardiovascular disease risk.
Researchers enrolled 3,302 premenopausal women not using hormone therapy between the ages of 42 and 52 and followed them annually for over 11 years for sociodemographic, lifestyle and clinical factors.
Results appeared online at the Journal of the American College of Cardiology.
Among the women, 1,769 reached natural menopause, 77 underwent a hysterectomy with ovarian conservation, and 106 women had a hysterectomy with bilateral oophorectomy. Cardiovascular risk factors did not vary annually by group with few exceptions, and the significant group differences that did emerge did not suggest an increased cardiovascular disease risk.
These results should reassure women and clinicians that hysterectomy in mid-life is unlikely to accelerate cardiovascular risk, the authors noted.
"The influence of natural and hysterectomy with or without ovarian conservation was similar for HDL-C, LDL-C, ApoB, HOMA-IR, SBP, PAI-1, and Factor VIIc over time," the authors wrote. "Several CVD risk factor changes did differ during the intervals prior to and following hysterectomy, compared to the changes prior to and following FMP (first menstrual period), but not in a pattern suggesting increasing cardiovascular risk following hysterectomy."