Blog | Wednesday, August 21, 2013

QD: News Every Day--Risk score might predict dementia risk among diabetics


A risk score based on easily obtainable factors can help clinicians predict which of their diabetic patients might develop dementia within 10 years, a study found.

Researchers created the model using data from nearly 30,000 patients ages 60 and older with type 2 diabetes for 10 years and validated it on a cohort of nearly 2,500 patients.

Results appeared in The Lancet Diabetes & Endocrinology.

Eight factors were most strongly predictive: microvascular disease, diabetic foot, cerebrovascular disease, cardiovascular disease, acute metabolic events, depression, age, and education (C statistic 0.736 for the creation cohort and 0.746 for the validation cohort). The dementia risk was 5.3% (95% confidence interval, 4.2% to 6.3%) for the lowest score of -1 and 73.3% (95% CI, 64.8% to 81.8%) for the highest scores ranging from 12 to 19.

Researchers noted that the eight predictors are easy to obtain and based primarily on medical history, which can be calculated during a routine medical visit or from the medical record.