Blog | Thursday, February 6, 2014

Bacteriophages and the spread of antimicrobial resistance


One component of the human microbiome which is garnering more attention lately is the “phageome” or “virome,” that portion of our microbial ecosystem comprised of viruses (phages) that infect and replicate within bacteria. A recent Nature paper demonstrated that antibiotic treatment of mice resulted in an expansion of phages bearing antibiotic resistance genes that could then spread back to wild-type bacteria and confer resistance. In this month’s issue of Antimicrobial Agents and Chemotherapy, a group from Spain examined the phage DNA in fecal samples of 80 healthy adults. Almost 80% of the samples revealed 1 or more of the 6 genes they sought (genes encoding 2 beta-lactamases (TEM and CTX-M), methicillin resistance (mecA), high-level aminoglycoside resistance (armA) and quinolone resistance (qnrA and qnrS).

Phages survive well in the environment, probably better than do their bacterial hosts. In addition, they aren’t detected using culture methods designed to find resistant bacteria. They almost certainly play a key role in the transmission of antimicrobial resistance genes.

Daniel J. Diekema, MD, FACP, practices infectious diseases, clinical microbiology, and hospital epidemiology in Iowa City, Iowa, splitting time between seeing patients with infectious diseases, diagnosing infections in the microbiology laboratory, and trying to prevent infections in the hospital. This post originally appeared at the blog Controversies in Hospital Infection Prevention.