Blog | Thursday, September 6, 2012

QD: News Every Day--Kidney stones associated with later renal disease

Just one kidney stone is associated with adverse renal conditions later in life, including more than twice the chance of end-stage renal disease (ESRD), a study found, even though the absolute risk is small.

To investigate whether the presence of kidney stones increase the risk of end stage renal disease (ESRD) or other adverse renal outcomes, researchers reviewed records from more than 3 million people in a registry cohort study in Alberta, Canada, between 1997 and 2009.

Results appeared in BMJ.

In the study, 0.8% patients had at least one kidney stone, 5,333 (0.2%) developed ESRD, 68,525 (4%) developed stage 3b–5 chronic kidney disease (estimated glomerular filtration rate less than 45 mL/min/1.73 m2), and 6,581 (0.3%) had sustained doubling of serum creatinine.

One or more kidneys tones was associated with increased risk of ESRD (adjusted hazard ratio [HR], 2.16; 95% confidence interval [CI], 1.79 to 2.62), new stage 3b-5 chronic kidney disease (HR, 1.74; 95% CI, 1.61 to 1.88), and doubling of serum creatinine (HR, 1.94; 95% CI, 1.56 to 2.43), compared to those without kidney stones.

The absolute increase in the rate of adverse renal outcomes associated with stones was small, the researchers noted. The unadjusted rate of ESRD was 2.48 per million person days in people with one or more episodes of stones versus 0.52 per million person days in people without kidney stones.