Blog | Monday, June 24, 2013

QD: News Every Day--HPV rates fall in post-vaccine era despite low inoculation rates

Prevalence of the four human papilloma virus (HPV) types susceptible to the vaccine have fallen by more than half in the past four years, despite less than a third of teen girls receiving the complete series of three doses, a study found

HPV vaccination using the quadrivalent vaccine (HPV-6, -11, -16, and -18) was introduced into the routine immunization schedule in the United States in late 2006 for girls ages 11 or 12 years, with catch-up vaccination recommended for ages 13 to 26. A 2010 national survey found that 49% of teenage girls ages 13 to 17 had received at least one dose and that 32% had received three doses

A study reported results in The Journal of Infectious Diseases.

Among girls ages 14 to 19, prevalence of the four HPV types covered by the vaccine decreased from 11.5% (95% confidence interval [CI], 9.2 to 14.4) in 2003-2006 to 5.1% (95% CI, 3.8 to 6.6) in 2007-2010, a decline of 56% (95% CI, 38% to 69%).

Among groups outside the recommended ages, prevalence did not differ significantly between the two time periods (P greater than .05). The vaccine effectiveness of at least one dose was 82% (95% CI, 53% to 93%).

Researchers wrote, "This decline is encouraging, given the substantial health and economic burden of HPV-associated disease."